The Big 5 Polynucleotides Treatments
The Age of Regeneration: The Science of Polynucleotides: Skin Renewal from Within
For decades, the world of aesthetics was focused on “filling” and “freezing.” But a new era has arrived – one that doesn’t just mask the signs of aging but actually reprograms your skin to act younger.
Welcome to the world of Polynucleotides, the breakthrough regenerative treatment that is currently one the most talked-about innovation in London’s elite skin clinics. At NAR LONDON, we are proud to be the city’s leading destination for these bio-stimulating injectables, offering a curated selection of the world’s most advanced products.
What are Polynucleotides?
Polynucleotides (PN) are long chains of nucleotides — the building blocks of DNA — derived from highly purified salmon or trout sperm DNA. They carry no genetic information; instead, they act as powerful biological signals that stimulate fibroblast activity, promote collagen and elastin synthesis, and create an optimal environment for cellular repair.
When injected into the dermis, polynucleotides attract growth factors, increase local hydration by binding water molecules, and reduce oxidative stress — one of the primary drivers of premature ageing. The result is not a surface-level change but a genuine, progressive improvement in skin quality, density and tone that develops over weeks and continues to improve with each treatment.
Polynucleotides stimulate fibroblasts — the cells responsible for producing collagen, elastin and hyaluronic acid — directly at the injection site. By providing a biocompatible substrate for cellular interaction, they upregulate growth factor release, accelerate tissue repair, and modulate inflammation. Clinical studies consistently demonstrate measurable increases in dermal thickness and elasticity after a course of treatment.
Polynucleotides vs Dermal Fillers?
Unlike traditional dermal fillers, which use Hyaluronic Acid to add volume, Polynucleotides when injected into the skin act as “biological messengers.” They signal your cells (fibroblasts) to repair damage, reduce inflammation, and most importantly produce fresh, high-quality collagen and elastin.
It isn’t just a “glow”; it is cellular repair.
Leading Polynucleotide Treatments
Not all polynucleotide products are alike. Concentration, molecular weight, purity protocols and formulation philosophy differ significantly between brands – making the expertise of your injector and clinic as important as the product itself. NAR LONDON works exclusively with the most clinically validated formulations available.
At NAR LONDON, we don’t believe in a one-size-fits-all approach. We utilise the “Big Five” of the polynucleotide world to tailor treatments to your specific skin needs:
1. Plinest: The Gold Standard
Origin: Italy · Pure PN · Mastelli Laboratories
Plinest, from the renowned Italian Mastelli Laboratories, is one of the most highly purified polynucleotide products available. Its exceptionally clean formulation minimises the risk of adverse reactions and maximises cellular uptake, making it the preferred choice for sensitive skin, reactive complexions, and patients with previous aesthetic procedure histories. Plinest’s versatility — injectable, topical and thread-based variants — makes it uniquely adaptable across treatment plans.
Key benefits:
- Exceptionally high purity — minimises reaction risk
- Available in injectable, topical and thread formats
- Ideal for sensitive or reactive skin types
- Synergistic with laser, microneedling and PRP
- Effective for scalp and hair thinning concerns
- Backed by extensive Italian clinical research
The original pioneer in the field. Plinest is highly effective for overall skin rejuvenation and is our go-to for the delicate eye area (Plinest Eye). It thickens the skin and improves elasticity without the puffiness associated with traditional fillers.
2. Newest: The Hybrid Powerhouse
Origin: South Korea · Advanced PN Gel
A newer entrant combining polynucleotides with a biorevitalising gel matrix, Newest offers a hybrid approach — the regenerative power of PN alongside immediate volumising and hydrating benefits. It is an excellent choice for patients wanting both structural improvement and a refreshed, luminous complexion from their first session.
Key benefits:
- Hybrid PN and gel formulation for dual-action results
- Visible radiance boost from the first treatment
- Excellent for skin dullness, fatigue and dehydration
- Ideal for first-time polynucleotide patients
Newest is a “genius” formula that combines Polynucleotides with Hyaluronic Acid. It is the perfect choice for more mature or severely dehydrated skin, providing the immediate plumping effect of HA with the long-term regenerative benefits of DNA repair.
3. NucleoFill: The Bio-Restructuring Lift
Origin: Italy · High-Concentration Polynucleotides
NucleoFill is an Italian-engineered polynucleotide distinguished by its exceptional purity and innovative formulation. Available in multiple concentrations – Medium, Strong, and the specialist Lips and Eyes variants – it is designed to deliver targeted biostimulation with precision. Its high PN concentration makes it particularly effective for patients seeking more rapid or intensive skin regeneration.
Key benefits:
- Multiple concentration options for tailored treatment
- Specialist formulas for the periocular areas (NucleoFill Eyes)
- Superior hydration and skin plumping effect
- Excellent for advanced skin laxity and volume loss
NucleoFill is famous for its “lifting” effect. It works deeply within the tissue to contour and firm the face. It is an excellent alternative for those who want a more defined jawline or cheekbone area without looking “puffy” or overfilled.
4. Ameela (formerly Nucleadyn): High-Concentration Repair
Origin: Italy · PDRN Complex
Ameela represents a new generation of combination polynucleotide therapy, pairing PDRN with complementary actives to amplify regenerative results. With dedicated formulations for face, eye and body, Ameela delivers a holistic approach to skin renewal — addressing not just the face but décolletage, neck, hands and other commonly neglected areas.
Key benefits:
- Dedicated face, eye and body formulations
- Enhanced hydration alongside structural regeneration
- Effective for neck, décolletage and hand rejuvenation
- Progressive, natural-looking improvement over time
Ameela is a high-viscosity polynucleotide gel that excels at treating sagging skin and deep-set wrinkles. It is particularly effective for the “jowl” area and the neck, offering a significant tightening effect through intense bio-stimulation.
5. Rejuran: The “Skin Healer”
Origin: South Korea · PDRN Technology
The original and still the gold standard in polynucleotide therapy, Rejuran was developed in South Korea and has an exceptional two-decade clinical track record. Its PDRN (polydeoxyribonucleotide) formulation promotes profound skin healing, dramatically improves texture, and addresses the fine crepe-like quality that develops in ageing or sun-damaged skin. Particularly effective for under-eye rejuvenation, acne scarring and overall skin quality improvement.
Key benefits:
- Stimulates collagen and elastin production deep within the dermis
- Repairs UV and environmental damage at a cellular level
- Improves pore size, texture and skin tone uniformly
- Ideal for under-eye hollowing, crepey skin and acne scarring
- Safe for delicate periorbital and perioral zones
Hailing from the cutting-edge labs of South Korea, Rejuran (often called the “Healer”) is world-renowned for its ability to treat acne scarring, enlarged pores, and sun damage. It creates a smooth, glass-like skin texture that is highly coveted in modern aesthetics.
Who Should Consider Treatment?
Polynucleotide treatments are among the most broadly applicable aesthetic interventions available – suitable for patients in their late twenties through to their seventies, across all skin types and tones. They are particularly well-suited to those experiencing early signs of skin ageing, loss of skin quality or density, under-eye hollowing, acne scarring, photodamage, or patients seeking to maintain and build upon results from other treatments.
They are also increasingly recommended as a preparatory or complementary treatment alongside surgical and energy-based procedures, optimising the skin’s regenerative capacity before treatment and accelerating healing and results thereafter.
Polynucleotides don’t mask ageing – they reverse it at the level where it begins: within the skin’s own cellular architecture.
What to Expect
A typical course consists of three to four sessions spaced three to four weeks apart, followed by maintenance treatments every four to six months. Results are cumulative — each treatment builds upon the last, triggering deeper and more sustained regenerative responses.
Step 1: Consultation: In-depth skin assessment and bespoke treatment plan.
Step 2: Treatment: 30–45 minute session with topical anaesthetic applied.
Step 3: Recovery: Minimal downtime – mild redness resolving within 24/48 hours.
Step 4: Results: Progressive improvement over 4–6 weeks, peaking after a full course.
Why NAR LONDON is the Leading Clinic for Regenerative Treatments?
NAR London is the capital’s foremost destination for polynucleotide and regenerative aesthetic treatments. Founded on a commitment to scientific rigour, clinical excellence and individualised care, NAR brings together London’s most experienced aesthetic practitioners with an exclusive range of the world’s most advanced PN formulations.
Every treatment at NAR LONDON begins with a comprehensive skin consultation – assessing skin biology, lifestyle factors, and long-term aesthetic goals to design a regenerative programme that delivers transformative, lasting results.
What separates NAR London from the growing number of clinics offering polynucleotide treatments is a combination of clinical depth and genuine product expertise. The team does not offer a single product and apply it universally – instead, each patient receives a considered assessment to determine which polynucleotide formulation, concentration and technique will deliver optimal results for their specific skin biology and concerns.
Our practitioner is trained directly with the leading PN brands, attend international aesthetic congresses, and remain at the forefront of emerging research. This means patients benefit not just from today’s gold-standard protocols, but from an evolving understanding of how regenerative science continues to advance.
Located in World famous Harley Street, the clinic offers a discreet, unhurried environment where clinical excellence and patient wellbeing are equally prioritised. Consultations are never rushed. Treatment plans are never generic. Results, consistently, speak for themselves.
Whether you are new to aesthetics or a seasoned patient seeking next-level skin health, NAR LONDON offers the expertise, products and precision that set results apart.
Regenerate Your Skin
Whether you are looking to brighten dark under-eye circles, firm a softening jawline, or simply “prime” your skin for the best health of its life, Polynucleotides are the answer.
Experience the future of aesthetics at the clinic that is leading the way.
BOOK YOUR CONSULTATION OR TREATMENT OF YOUR CHOICE AT NAR LONDON – Discover the power of DNA-driven skin repair.